BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. As a potent osteoinductive cytokine, BMP-2 is capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. BMP-2 wild type binds to its cellular receptors via two distinct binding epitopes. The large epitope 1 is responsible for the high-affinity binding to the BMPR-IA receptor, the smaller epitope 2 provides the low-affinity binding to the receptor BMPR-II. BMP-2 expressed in human 293 cells offers authentic glycosylation which contributes to stability in cell growth media and other applications. BMP-2 expressed from human 293 cells is a disulfide linked homodimeric glycoprotein with an molecular mass of 28 kDa.

Cell Biologics细胞生物制剂公司总部位于美国芝加哥，是全球独家提供Jackson Lab基因敲除小鼠原代细胞的专业公司，产品已获美国农业部SPF认证，并经中国进出口商品检验检疫局检验准许进口 自 成立以来，Cell Biologics已开发出13个品系1,000多种可直接使用的JacksonLab基因敲除小鼠、正常野生型小鼠、大鼠原代细胞，必将填补细胞生物学 界研究的空白。另外，Cell Biologics拥有AAALAC认证的动物实验室，提供JacksonLab与国外其他著名实验室所有允许商用的基因敲除小鼠原代细胞分离服务